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Click Here To Call Us NowMississippi County is the easternmost county in the U.S. state of Arkansas. As of the 2020 census, the population was 40,685. There are two county seats, Blytheville and Osceola. The county was formed on November 1, 1833, and named for the Mississippi River which borders the county to the east. Mississippi County is part of the First Congressional District in Arkansas.